https://organelles.org/index.php/organelle <p><span style="font-weight: 400;">The specialized structures within a cell that we know as organelles have crucial and still fascinatingly mysterious influence in the larger story of an organism. Today our understanding of organelles and their dynamics, including morphological changes, biogenesis, trafficking, or interplaying among different organelles is evolving. Research investigating these dynamics and molecular mechanisms, especially in the context of the pathophysiology of human diseases, is essential and has only just begun. What we understand about organelles and their role in human diseases can be expected to expand greatly and </span><em><span style="font-weight: 400;">Organelle</span></em><span style="font-weight: 400;"> is dedicated to making that happen. </span></p> en-US editor@organelles.org (Xinglong Wang) editor@organelles.org (Victoria Vega) Fri, 08 Nov 2024 10:17:41 -0800 OJS 3.3.0.7 http://blogs.law.harvard.edu/tech/rss 60 https://organelles.org/index.php/organelle/article/view/v1no2a1 <p><strong>Naked mole-rats (NMR, Heterocephalus glaber) are the longest-lived rodent species, with a maximum life span of more </strong><strong>than 30 years. These long-lived mammals exhibit delayed aging phenotypes and resistance to age-related pathologies including </strong><strong>neurodegeneration. Multiple regulatory pathways have been proposed for the anti-aging mechanisms in NMR including </strong><strong>enhanced mitochondrial function and suppressed oxidative stress. In this study, we investigated the assembly of the </strong><strong>electron transfer chain (ETC) which constitutes the structural base for the regulation of both oxidative phosphorylation </strong><strong>and the production of reactive oxygen species (ROS), in brains from young and old NMR and C57BL/6 mice. While </strong><strong>ETC assembly declined with aging in C57BL/6 mice, we found that NMR display a robust respiratory chain assembly at </strong><strong>older ages in both males and females. Among them, individual complex IV and supercomplexes containing complex I </strong><strong>and III or complex III and IV showed the most pronounced differences between two species. Our results indicate that a </strong><strong>preserved robust assembly of ETC during aging contributes to enhanced mitochondrial oxidative phosphorylation and </strong><strong>suppressed oxidative stress, which may contribute to the longevity and resistance to age-related pathologies in NMR.</strong></p> Ting Liang, Belinda Bernal, Wenbo Qi, Yuji Ikeno, Adam Salmon, Daisy Kwok, Joel Michalek, Mai Zhou, Yidong Bai Copyright (c) 2024 Organelle https://creativecommons.org/licenses/by/4.0 https://organelles.org/index.php/organelle/article/view/v1no2a1 Fri, 08 Nov 2024 00:00:00 -0800